Model 1600 Neuroprobe Amplifier

• Impedance: 10¹¹Ω
• Capacitance: Adjustable to zero
• Working Range: ± 2.5 V
• Maximum Range: ± 10 V
• Iontophoresis Adapter Input: ± 200 V

• Input Impedance: 20 kΩ
• Frequency Range: DC to 250 kHz
• Low Range Maximum Current: 10 nA/V
• Low Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 10⁸ VΩ)/(electrode resistance)
• High Range Maximum Current: 100 nA/V
• High Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 10⁷ VΩ)/(electrode resistance)

• Low Range Maximum Current: lesser of ± 100 nA and 2.5 V/(electrode resistance)
• Low Range Maximum Voltage: lesser of ± 1000 nA and 2.5 V/(electrode resistance)

• ON Signal: + 2.5 V (Step with rise time 10 µsec)
• OFF Signal: +0.6 V
• Maximum Input: ± 15 V
• Input Impedance 20 kΩ

• Input Impedance: 10 kΩ
• Input Voltage Range: ± 10 V
• Low Range Scale Factor (x1 Output): 1 mV/MΩ/(input voltage)
• High Range Scale Factor (x1 Output): 10 mV/MΩ/(input voltage)

• Signal: 100 Hz Square Wave
• Low Range Scale Factor (x1 Output): 1 nA p-p produces 1 mV/MΩ
• High Range Scale Factor (x1 Output): 10 nA p-p produces 1 mV/MΩ

• Optimal: Adjustable to Zero
• Maximum without adjustment, Low Range: 3x10^-12 Amp
• Maximum without adjustment, High Range: 3x10^-11Amp
• Drift vs Temperature, Low Range: 1x10^-13 Amp/°C
• Drift vs Temperature, High Range: 1x10^-12 Amp/°C
• Drift vs Time, Low Range: 3x10^-13 Amp/12 hours
• Drift vs Time, High Range: 3x10^-12 Amp/12 hours

• Frequency Range: DC to 325 kHz

• Square Wave (500 mV) 50 Ω Source: 0.8 µsec (10% to 90%)
• Square Wave (500 mV) 20 MΩ Source: 7.0µsec (10% to 90%)

• Stability vs Temperature: 200 µV/°C
• Stability vs Time:1 mV/12 hours

• Cut-off Frequencies (-3 dB): 1, 2, 5, 10, 20, 50, 100 kHz
• Slope: -12 dB/octave

• Center Frequency: 50 Hz or 60 Hz (factory preset)
• Q: 10
• Rejection: -50 dB

• Range: -4 pF to +30 pF

• 10mV: ± 1%
• 1000mV: ± 1%

• 0 Ω Source: 13 µV RMS (10Hz to 50kHz)
• 1 MΩ Source: 79 µV RMS (10Hz to 50kHz)
• 20 MΩ Source: 310 µV RMS (10Hz to 50kHz)

• Low Range: up to 500 MΩ
• High Range: up to 50 MΩ

• Voltage Gain: 1.00 ± 0.1%
• Maximum Voltage: ± 10V
• Impedance: 220 Ω
• DC Offset Range: 0.0 V to ± 1.0 V

• Voltage Gain: 10.00 ± 1.0%
• Maximum Voltage: ± 10 V
• Impedance: 220 Ω
• DC Offset Range: 0.0 V to ± 10.0 V

• Low Range Scale Factor: 10 mV/nA
• High Range Scale Facto: 1 mV/nA
• Maximum Output: ± 1.0 V
• Output Impedance: 1 kΩ

Headstage for Model 1600

The Head Stage for the Neuroprobe Amplifier is designed to assure the user flexibility in application as well as optimum recordings. It can be mounted in a standard micromanipulator in either straight-on or 90 degree configurations.

The headstage has a standard 2 mm (0.08") pin connector jack for use with half-cell microelectrode holders.

The head stage features an internal driven shield to be placed around the body of the electrode from reduced capacitance and noise. It houses a wide bandwidth, FET-input operational amplifier and current injection and capacitance compensation components. The input impedance is typically 10¹⁴ Ohms; the input current is typically less than 1.0 pA; the bandwidth is greater than 325 kHz. All metal parts are chrome-plated to resist corrosion. The flexible 5' cable is silicone jacketed to resist mild alkalis, acids and solvents.

Iontophoresis Adapter for Model 1600

An Iontophoresis Adapter Model 6820 is available for use with the Model 1600 Neuroprobe Amplifier to apply high voltages to the micropipette for iontophoretic injection of drugs or dyes, or any other application where currents greater than those provided by the Model 1600 are required.

The Model 6820 is connected between the Headstage Probe and the Model 1600. When the 6820 selector switch is in the EXT position, up to ±200 V can be applied to the electrode to permit injection of dyes or drugs into the cell. The injection current equals the voltage applied to the + and - terminals on the Model 6820 divided by the sum of the electrode resistance and the 9.0 MΩ protective resistance of the Headstage. The - terminal on the Model 6820 is connected internally to the system GND.

If the switch is set to the INT position, routine recording and injecting operations can be performed with the Model 1600 as if the Model 6820 were not present.